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| GUIDOLIN,R.; STEPHANO,M. A.; MORAIS,J. F.; SAKAGUTI,E. H.; PRADO,S. M. A.; FRATELLI,F.; VANCETTO,M. D. C.; HIGASHI,H. G.. |
| The present investigation reveals the possibility of simultaneous immunization of horses with Bothrops or Crotalus snake venoms and Tetanus antigens for the production of anti-Bothrops-Tetanus or anti-Crotalus-Tetanus mixed serum, with high titers of the respective specific antibodies. Bothrops antivenoms with an average neutralizing titer of 4.16 mg venom/ml were obtained from plasma of horses with titers lower than 0.5 mg venom/ml when Tetanus antigens were not used. This suggests the existence of a synergism between Bothrops venoms and Tetanus antigens in the stimulation of the antibody response. The pooled plasma of the animals had a neutralizing titer of 21.0 mg/ml reference Bothrops venoms and 3,300 IU/ml to Tetanus antigens after purification by... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antivenoms; Immunization; Bothrops; Tetanus. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301998000100007 |
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